X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

Wenpei Fan; Wenbo Bu; Zhen Zhang; Bo Shen; Hui Zhang; Qianjun He; Dalong Ni; Zhaowen Cui; Kuaile Zhao; Jiwen Bu; Jiulin Du; Jianan Liu; Jianlin Shi

doi:10.1002/anie.201504536

X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

Wenpei Fan
, Wenbo Bu^*
, Zhen Zhang
, Bo Shen
, Hui Zhang
, Qianjun He
, Dalong Ni
, Zhaowen Cui
, Kuaile Zhao
, Jiwen Bu
, Jiulin Du
, Jianan Liu
, Jianlin Shi

^*此作品的通讯作者

CAS - Shanghai Institute of Ceramics
Fudan University
CAS - Shanghai Institute of Nutrition and Health

科研成果: 期刊稿件 › 文章 › 同行评审

278 引用（Scopus）

摘要

Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.

源语言	英语
页（从-至）	14026-14030
页数	5
期刊	Angewandte Chemie - International Edition
卷	54
期	47
DOI	https://doi.org/10.1002/anie.201504536
出版状态	已出版 - 16 11月 2015
已对外发布	是

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title = "X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization",

abstract = "Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.",

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AU - Fan, Wenpei

AU - Bu, Wenbo

AU - Zhang, Zhen

AU - Shen, Bo

AU - Zhang, Hui

AU - He, Qianjun

AU - Ni, Dalong

AU - Cui, Zhaowen

AU - Zhao, Kuaile

AU - Bu, Jiwen

AU - Du, Jiulin

AU - Liu, Jianan

AU - Shi, Jianlin

PY - 2015/11/16

Y1 - 2015/11/16

N2 - Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.

AB - Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs invitro and invivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.

KW - NO release

KW - X-ray radiation

KW - hypoxic radiosensitization

KW - luminescent imaging

KW - on-demand therapy

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X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

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