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When SLC46A2 delivers cargo into keratinocytes

  • East China Normal University

科研成果: 期刊稿件评论/辩论

摘要

How pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides from extracellular bacteria to drive keratinocyte inflammation remains unclear. In this issue of Immunity, Bharadwaj et al. show that the solute carrier 46A2 (SLC46A2) delivers DAP-muropeptides into the cytosol to drive NOD1 activation in keratinocytes and elicit skin inflammation during psoriasis.

源语言英语
页(从-至)897-900
页数4
期刊Immunity
56
5
DOI
出版状态已出版 - 9 5月 2023

联合国可持续发展目标

此成果有助于实现下列可持续发展目标:

  1. 可持续发展目标 3 - 良好健康与福祉
    可持续发展目标 3 良好健康与福祉

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