Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF3 γ-keto esters that uses Ph3PO as catalyst for the chemoselective conjugate reduction

Long Chen; Tao Da Shi; Jian Zhou

doi:10.1002/asia.201201130

Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF₃ γ-keto esters that uses Ph₃PO as catalyst for the chemoselective conjugate reduction

Long Chen
, Tao Da Shi
, Jian Zhou^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

39 引用（Scopus）

摘要

Reduce your waist: A highly efficient synthesis of α-CF₃ γ-keto esters and trifluoromethylated 4,5-dihydro pyridazinones is reported based on tandem Wittig-conjugate reduction reactions, which directly utilize the Ph₃PO waste from the Wittig reaction as the Lewis base catalyst to activate HSiCl₃ for the chemoselective conjugate reduction.

源语言	英语
页（从-至）	556-559
页数	4
期刊	Chemistry - An Asian Journal
卷	8
期	3
DOI	https://doi.org/10.1002/asia.201201130
出版状态	已出版 - 3月 2013

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10.1002/asia.201201130

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引用此

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title = "Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF3 γ-keto esters that uses Ph3PO as catalyst for the chemoselective conjugate reduction",

abstract = "Reduce your waist: A highly efficient synthesis of α-CF3 γ-keto esters and trifluoromethylated 4,5-dihydro pyridazinones is reported based on tandem Wittig-conjugate reduction reactions, which directly utilize the Ph3PO waste from the Wittig reaction as the Lewis base catalyst to activate HSiCl3 for the chemoselective conjugate reduction.",

keywords = "Lewis bases, Wittig reaction, organocatalysis, reduction, waste as catalyst",

author = "Long Chen and Shi, \{Tao Da\} and Jian Zhou",

year = "2013",

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AU - Shi, Tao Da

AU - Zhou, Jian

PY - 2013/3

Y1 - 2013/3

N2 - Reduce your waist: A highly efficient synthesis of α-CF3 γ-keto esters and trifluoromethylated 4,5-dihydro pyridazinones is reported based on tandem Wittig-conjugate reduction reactions, which directly utilize the Ph3PO waste from the Wittig reaction as the Lewis base catalyst to activate HSiCl3 for the chemoselective conjugate reduction.

AB - Reduce your waist: A highly efficient synthesis of α-CF3 γ-keto esters and trifluoromethylated 4,5-dihydro pyridazinones is reported based on tandem Wittig-conjugate reduction reactions, which directly utilize the Ph3PO waste from the Wittig reaction as the Lewis base catalyst to activate HSiCl3 for the chemoselective conjugate reduction.

KW - Lewis bases

KW - Wittig reaction

KW - organocatalysis

KW - reduction

KW - waste as catalyst

UR - https://www.scopus.com/pages/publications/84874251994

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DO - 10.1002/asia.201201130

M3 - 文章

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SN - 1861-4728

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IS - 3

ER -

Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF3 γ-keto esters that uses Ph3PO as catalyst for the chemoselective conjugate reduction

摘要

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Waste as catalyst: Tandem Wittig/conjugate reduction sequence to α-CF₃ γ-keto esters that uses Ph₃PO as catalyst for the chemoselective conjugate reduction