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Visual search in alzheimer's disease - FMERI study

  • Jing Hao*
  • , Kun Cheng Li
  • , Ke Li
  • , De Xuan Zhang
  • , Wei Wang
  • , Bin Yan
  • , Yan Hui Yang
  • , Yan Wang
  • , Qi Chen
  • , Bao Ci Shan
  • , Xiao Lin Zhou
  • *此作品的通讯作者
  • Capital Medical University
  • Peking University
  • CAS - Institute of High Energy Physics

科研成果: 书/报告/会议事项章节章节同行评审

摘要

The aim was to investigate the neural basis of visual attention deficits in Alzheimer's disease (AD) patients using functional MRI. Thirteen AD patients and 13 age-matched controls participated in the experiment of two visual search tasks, one was a pop-out task, the other was a conjunction task. The fMRI data were collected on a 1. 5T MRI system and analyzed by SPM99. Both groups revealed almost the same networks engaged in both tasks, including the superior parietal lobule (SPL), frontal and occipito-temporal cortical regions (OTC), primary visual cortex and some subcortical structures. AD patients have a particular impairment in the conjunction task. The most pronounced differences were more activity in the SPL in controls and more activity in the OTC in AD patients. These results imply that the mechanisms controlling spatial shifts of attention are impaired in AD patients.

源语言英语
主期刊名Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
编辑Guang-Zhong Yang, Tianzi Jiang
出版商Springer Verlag
204-212
页数9
ISBN(印刷版)3540228772, 9783540228776
DOI
出版状态已出版 - 2004
已对外发布

出版系列

姓名Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
3150
ISSN(印刷版)0302-9743
ISSN(电子版)1611-3349

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