Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

Na Lu; Anran Gao; Pengfei Dai; Hongju Mao; Yuelin Wang; Tie Li

Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

Na Lu
, Anran Gao
, Pengfei Dai
, Hongju Mao
, Yuelin Wang
, Tie Li^*

^*此作品的通讯作者

CAS - Shanghai Institute of Microsystem and Information Technology

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

摘要

CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.

源语言	英语
主期刊名	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
出版商	Chemical and Biological Microsystems Society
页	2178-2180
页数	3
ISBN（电子版）	9780979806476
出版状态	已出版 - 2014
已对外发布	是
活动	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, 美国期限: 26 10月 2014 → 30 10月 2014

出版系列

姓名	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

会议

会议	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
国家/地区	美国
市	San Antonio
时期	26/10/14 → 30/10/14

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

其它文件与链接

链接到 Scopus 的出版物

引用此

Lu, N., Gao, A., Dai, P., Mao, H., Wang, Y., & Li, T. (2014). Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. 在 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (页码 2178-2180). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

Lu, Na ; Gao, Anran ; Dai, Pengfei 等. / Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. 页码 2178-2180 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

@inproceedings{31133a53d99b43b4b9baf5b4850e6a9d,

title = "Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors",

abstract = "CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.",

keywords = "CYFRA21-1, Label-free, Silicon nanowire field-effect-transistors (SiNW-FETs), Ultrasensitive",

author = "Na Lu and Anran Gao and Pengfei Dai and Hongju Mao and Yuelin Wang and Tie Li",

note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

year = "2014",

language = "英语",

series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

pages = "2178--2180",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

}

Lu, N, Gao, A, Dai, P, Mao, H, Wang, Y & Li, T 2014, Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. 在 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, 页码 2178-2180, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, 美国, 26/10/14.

Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. / Lu, Na; Gao, Anran; Dai, Pengfei 等.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. 页码 2178-2180 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

TY - GEN

T1 - Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

AU - Lu, Na

AU - Gao, Anran

AU - Dai, Pengfei

AU - Mao, Hongju

AU - Wang, Yuelin

AU - Li, Tie

PY - 2014

Y1 - 2014

N2 - CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.

AB - CYFRA 21-1 was reported as the best concordance with NSCLC response, which has considerable potential for early diagnostic and prognosis of NSCLC. However, current methods for CYFRA 21-1 detection suffered from labor-intensive steps, low sensitivity, and high cost. Here we proposed a CMOS-compatible silicon nanowire field-effect-transistors (SiNW-FETs) with integrated PDMS microfluidic sample delivery system for ultrasensitive, label-free, and real-time detection of CYFRA 21-1. The nanosensors demonstrated a high sensitivity of CYFRA 21-1 as low as 1fg/mL, as well as good selectivity for other lung cancer biomarker CEA.

KW - CYFRA21-1

KW - Label-free

KW - Silicon nanowire field-effect-transistors (SiNW-FETs)

KW - Ultrasensitive

UR - https://www.scopus.com/pages/publications/84941656392

M3 - 会议稿件

AN - SCOPUS:84941656392

T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

SP - 2178

EP - 2180

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Lu N, Gao A, Dai P, Mao H, Wang Y, Li T. Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors. 在 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. 页码 2178-2180. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Ultrasensitive and label-free detection of CYFRA21-1 using CMOS-compatible silicon nanowire biosensors

摘要

出版系列

会议

联合国可持续发展目标

其它文件与链接

指纹

引用此