Transmembrane anion transport mediated by the well-designed electron-rich resorcin[4]arenes

The design of anion receptors and transporters is of significant importance, particularly due to the unique selectivity provided by CH-based receptors. Recent research published in Chem by Agnieszka Szumna et al. presents an innovative approach to developing anion receptors and transporters utilizing resorcin[4]arenes. By substituting resorcin[4]arenes with nitro groups, the resulting receptors exhibit substantial dipole moments and concentrated electrostatic potentials, which lead to high anion affinities and efficient transport capabilities. Furthermore, the incorporation of alkyl chains at the anion-binding site enhances the receptors’ water resistance, thereby enabling highly efficient anion transport across lipid bilayers.