Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Wei Tan; Niklas Jänsch; Tina Öhlmann; Franz Josef Meyer-Almes; Xuefeng Jiang

doi:10.1021/acs.orglett.9b02784

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Wei Tan
, Niklas Jänsch
, Tina Öhlmann
, Franz Josef Meyer-Almes^*
, Xuefeng Jiang

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Darmstadt University of Applied Sciences
Nankai University

科研成果: 期刊稿件 › 文章 › 同行评审

35 引用（Scopus）

摘要

An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.

源语言	英语
页（从-至）	7484-7488
页数	5
期刊	Organic Letters
卷	21
期	18
DOI	https://doi.org/10.1021/acs.orglett.9b02784
出版状态	已出版 - 20 9月 2019

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abstract = "An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.",

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AU - Tan, Wei

AU - Jänsch, Niklas

AU - Öhlmann, Tina

AU - Meyer-Almes, Franz Josef

AU - Jiang, Xuefeng

PY - 2019/9/20

Y1 - 2019/9/20

N2 - An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.

AB - An efficient and practical thiocarbonyl surrogate via combination of potassium sulfide and chloroform was established. A variety of dithiocarbamates were afforded along with four new chemical bond formations in a one-pot reaction in which the thiocarbonyl motif was generated in situ. Furthermore, these readily accessed molecules showed promising activity against HDAC8, opening a potential gateway to discover a new type of nonhydroxamate and isoenzyme-selective HDAC inhibitors.

UR - https://www.scopus.com/pages/publications/85072546231

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DO - 10.1021/acs.orglett.9b02784

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AN - SCOPUS:85072546231

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JO - Organic Letters

JF - Organic Letters

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ER -

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

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