摘要
A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 μM photochemically. Mechanism experiment showed that electron transfer and radicals were involved.
| 源语言 | 英语 |
|---|---|
| 页(从-至) | 3513-3515 |
| 页数 | 3 |
| 期刊 | Bioorganic and Medicinal Chemistry Letters |
| 卷 | 13 |
| 期 | 20 |
| DOI | |
| 出版状态 | 已出版 - 20 10月 2003 |
| 已对外发布 | 是 |
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