The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

Xuan Zhang; Jie Zhang; Linjiang Tong; Yu Luo; Mingbo Su; Yi Zang; Jia Li; Wei Lu; Yi Chen

doi:10.1016/j.bmc.2013.03.049

The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

Xuan Zhang
, Jie Zhang
, Linjiang Tong
, Yu Luo
, Mingbo Su
, Yi Zang
, Jia Li
, Wei Lu^*
, Yi Chen

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
CAS - Shanghai Institute of Materia Medica

科研成果: 期刊稿件 › 文章 › 同行评审

71 引用（Scopus）

摘要

A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors. To the best of our knowledge, this is the first design of molecules that are dual inhibitors of tubulin and HDAC. Biological evaluations of these compounds included the inhibitory activity of HDAC, in vitro cell cycle analysis in BEL-7402 cells as well as cytotoxicity in five cancer cell lines.

源语言	英语
页（从-至）	3240-3244
页数	5
期刊	Bioorganic and Medicinal Chemistry
卷	21
期	11
DOI	https://doi.org/10.1016/j.bmc.2013.03.049
出版状态	已出版 - 1 6月 2013

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1016/j.bmc.2013.03.049

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title = "The discovery of colchicine-SAHA hybrids as a new class of antitumor agents",

abstract = "A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors. To the best of our knowledge, this is the first design of molecules that are dual inhibitors of tubulin and HDAC. Biological evaluations of these compounds included the inhibitory activity of HDAC, in vitro cell cycle analysis in BEL-7402 cells as well as cytotoxicity in five cancer cell lines.",

keywords = "Colchicine, HDAC, Hybrid, SAHA, Tubulin",

author = "Xuan Zhang and Jie Zhang and Linjiang Tong and Yu Luo and Mingbo Su and Yi Zang and Jia Li and Wei Lu and Yi Chen",

year = "2013",

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doi = "10.1016/j.bmc.2013.03.049",

language = "英语",

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T1 - The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

AU - Zhang, Xuan

AU - Zhang, Jie

AU - Tong, Linjiang

AU - Luo, Yu

AU - Su, Mingbo

AU - Zang, Yi

AU - Li, Jia

AU - Lu, Wei

AU - Chen, Yi

PY - 2013/6/1

Y1 - 2013/6/1

N2 - A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors. To the best of our knowledge, this is the first design of molecules that are dual inhibitors of tubulin and HDAC. Biological evaluations of these compounds included the inhibitory activity of HDAC, in vitro cell cycle analysis in BEL-7402 cells as well as cytotoxicity in five cancer cell lines.

AB - A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors. To the best of our knowledge, this is the first design of molecules that are dual inhibitors of tubulin and HDAC. Biological evaluations of these compounds included the inhibitory activity of HDAC, in vitro cell cycle analysis in BEL-7402 cells as well as cytotoxicity in five cancer cell lines.

KW - Colchicine

KW - HDAC

KW - Hybrid

KW - SAHA

KW - Tubulin

UR - https://www.scopus.com/pages/publications/84877794404

U2 - 10.1016/j.bmc.2013.03.049

DO - 10.1016/j.bmc.2013.03.049

M3 - 文章

C2 - 23602523

AN - SCOPUS:84877794404

SN - 0968-0896

VL - 21

SP - 3240

EP - 3244

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 11

ER -

The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

摘要

联合国可持续发展目标

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