Synthesis of the de synthon of racemic camptothecin

Shanbao Yu; Yu Luo; Haiyan Liu; Haomin Liu; Wei Lu

doi:10.1007/s00706-009-0245-0

Synthesis of the de synthon of racemic camptothecin

Shanbao Yu
, Yu Luo
, Haiyan Liu
, Haomin Liu
, Wei Lu^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29% overall yield.

源语言	英语
页（从-至）	245-249
页数	5
期刊	Monatshefte fur Chemie
卷	141
期	2
DOI	https://doi.org/10.1007/s00706-009-0245-0
出版状态	已出版 - 2月 2010

访问文件

10.1007/s00706-009-0245-0

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{11311d66dab1450b95f756b14b2c32ad,

title = "Synthesis of the de synthon of racemic camptothecin",

abstract = "A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29\% overall yield.",

keywords = "2-Chloronicotinic acid lithiation, Camptothecin, Lactone, Pyridone",

author = "Shanbao Yu and Yu Luo and Haiyan Liu and Haomin Liu and Wei Lu",

year = "2010",

month = feb,

doi = "10.1007/s00706-009-0245-0",

language = "英语",

volume = "141",

pages = "245--249",

journal = "Monatshefte fur Chemie",

issn = "0026-9247",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Synthesis of the de synthon of racemic camptothecin

AU - Yu, Shanbao

AU - Luo, Yu

AU - Liu, Haiyan

AU - Liu, Haomin

AU - Lu, Wei

PY - 2010/2

Y1 - 2010/2

N2 - A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29% overall yield.

AB - A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29% overall yield.

KW - 2-Chloronicotinic acid lithiation

KW - Camptothecin

KW - Lactone

KW - Pyridone

UR - https://www.scopus.com/pages/publications/77952582092

U2 - 10.1007/s00706-009-0245-0

DO - 10.1007/s00706-009-0245-0

M3 - 文章

AN - SCOPUS:77952582092

SN - 0026-9247

VL - 141

SP - 245

EP - 249

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

IS - 2

ER -

Synthesis of the de synthon of racemic camptothecin

摘要

访问文件

其它文件与链接

指纹

引用此