Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

Wei Gang Huang; Jing Ya Li; Yu Luo; Jia Li; Wei Lu

doi:10.1016/j.cclet.2009.07.008

Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

Wei Gang Huang
, Jing Ya Li
, Yu Luo^*
, Jia Li
, Wei Lu

^*此作品的通讯作者

化学与分子工程学院

CAS - Shanghai Institute of Materia Medica
East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

10 引用（Scopus）

摘要

Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC₅₀ values in very low micromolar range. At last, the preliminary SAR was discussed.

源语言	英语
页（从-至）	1461-1464
页数	4
期刊	Chinese Chemical Letters
卷	20
期	12
DOI	https://doi.org/10.1016/j.cclet.2009.07.008
出版状态	已出版 - 12月 2009

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10.1016/j.cclet.2009.07.008

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@article{b058dff84abb4d828cdc6e55dd2f5252,

title = "Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases",

abstract = "Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed.",

keywords = "Antitumor, Cdc25 phosphatases, Synthesis, Tanshinone IIA",

author = "Huang, \{Wei Gang\} and Li, \{Jing Ya\} and Yu Luo and Jia Li and Wei Lu",

year = "2009",

month = dec,

doi = "10.1016/j.cclet.2009.07.008",

language = "英语",

volume = "20",

pages = "1461--1464",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

AU - Huang, Wei Gang

AU - Li, Jing Ya

AU - Luo, Yu

AU - Li, Jia

AU - Lu, Wei

PY - 2009/12

Y1 - 2009/12

N2 - Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed.

AB - Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed.

KW - Antitumor

KW - Cdc25 phosphatases

KW - Synthesis

KW - Tanshinone IIA

UR - https://www.scopus.com/pages/publications/70349994100

U2 - 10.1016/j.cclet.2009.07.008

DO - 10.1016/j.cclet.2009.07.008

M3 - 文章

AN - SCOPUS:70349994100

SN - 1001-8417

VL - 20

SP - 1461

EP - 1464

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 12

ER -

Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

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