Synthesis of Spiro[5.n (n=6–8)]heterocycles through Successive Ring-Expansion/Indole C-2 Functionalization

Yang Yuan; Zixia Guo; Yuanyang Mu; Ye Wang; Murong Xu; Yanzhong Li

doi:10.1002/adsc.201901631

Synthesis of Spiro[5.n (n=6–8)]heterocycles through Successive Ring-Expansion/Indole C-2 Functionalization

Yang Yuan
, Zixia Guo
, Yuanyang Mu
, Ye Wang
, Murong Xu
, Yanzhong Li^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

22 引用（Scopus）

摘要

A cascade procedure for the efficient and atom-economical synthesis of spiro[5.n (n=6–8)]heterocycles has been developed. This process goes through the tandem reactions of base-promoted ring-expansion of cyclic ketones followed by Cu-catalyzed intramolecular C-2 spirocyclization of indoles. Easily accessible starting materials and broad substrate scope are the advantaged features of this protocol. (Figure presented.).

源语言	英语
页（从-至）	1298-1302
页数	5
期刊	Advanced Synthesis and Catalysis
卷	362
期	6
DOI	https://doi.org/10.1002/adsc.201901631
出版状态	已出版 - 17 3月 2020

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title = "Synthesis of Spiro[5.n (n=6{\textendash}8)]heterocycles through Successive Ring-Expansion/Indole C-2 Functionalization",

abstract = "A cascade procedure for the efficient and atom-economical synthesis of spiro[5.n (n=6{\textendash}8)]heterocycles has been developed. This process goes through the tandem reactions of base-promoted ring-expansion of cyclic ketones followed by Cu-catalyzed intramolecular C-2 spirocyclization of indoles. Easily accessible starting materials and broad substrate scope are the advantaged features of this protocol. (Figure presented.).",

keywords = "Csp−H functionalization, Cu-catalyzed, one-pot, ring-expansion, spiro[5.n (n=6{\textendash}8)]heterocycles",

author = "Yang Yuan and Zixia Guo and Yuanyang Mu and Ye Wang and Murong Xu and Yanzhong Li",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2020",

month = mar,

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doi = "10.1002/adsc.201901631",

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T1 - Synthesis of Spiro[5.n (n=6–8)]heterocycles through Successive Ring-Expansion/Indole C-2 Functionalization

AU - Yuan, Yang

AU - Guo, Zixia

AU - Mu, Yuanyang

AU - Wang, Ye

AU - Xu, Murong

AU - Li, Yanzhong

PY - 2020/3/17

Y1 - 2020/3/17

N2 - A cascade procedure for the efficient and atom-economical synthesis of spiro[5.n (n=6–8)]heterocycles has been developed. This process goes through the tandem reactions of base-promoted ring-expansion of cyclic ketones followed by Cu-catalyzed intramolecular C-2 spirocyclization of indoles. Easily accessible starting materials and broad substrate scope are the advantaged features of this protocol. (Figure presented.).

AB - A cascade procedure for the efficient and atom-economical synthesis of spiro[5.n (n=6–8)]heterocycles has been developed. This process goes through the tandem reactions of base-promoted ring-expansion of cyclic ketones followed by Cu-catalyzed intramolecular C-2 spirocyclization of indoles. Easily accessible starting materials and broad substrate scope are the advantaged features of this protocol. (Figure presented.).

KW - Csp−H functionalization

KW - Cu-catalyzed

KW - one-pot

KW - ring-expansion

KW - spiro[5.n (n=6–8)]heterocycles

UR - https://www.scopus.com/pages/publications/85079225867

U2 - 10.1002/adsc.201901631

DO - 10.1002/adsc.201901631

M3 - 文章

AN - SCOPUS:85079225867

SN - 1615-4150

VL - 362

SP - 1298

EP - 1302

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 6

ER -

Synthesis of Spiro[5.n (n=6–8)]heterocycles through Successive Ring-Expansion/Indole C-2 Functionalization

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