Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases

Weigang Huang; Jingya Li; Wei Zhang; Yueyang Zhou; Chuanming Xie; Yu Luo; Yunfei Li; Jingli Wang; Jia Li; Wei Lu

doi:10.1016/j.bmcl.2005.12.080

Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases

Weigang Huang
, Jingya Li^*
, Wei Zhang
, Yueyang Zhou
, Chuanming Xie
, Yu Luo
, Yunfei Li
, Jingli Wang
, Jia Li^*
, Wei Lu

^*此作品的通讯作者

化学与分子工程学院

CAS - Shanghai Institute of Materia Medica
East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

37 引用（Scopus）

摘要

Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC₅₀ values in the micromolar range.

源语言	英语
页（从-至）	1905-1908
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	16
期	7
DOI	https://doi.org/10.1016/j.bmcl.2005.12.080
出版状态	已出版 - 1 4月 2006

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1016/j.bmcl.2005.12.080

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title = "Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases",

abstract = "Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range.",

keywords = "Cancer, Cdc25 phosphatases, Miltirone",

author = "Weigang Huang and Jingya Li and Wei Zhang and Yueyang Zhou and Chuanming Xie and Yu Luo and Yunfei Li and Jingli Wang and Jia Li and Wei Lu",

year = "2006",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2005.12.080",

language = "英语",

volume = "16",

pages = "1905--1908",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases

AU - Huang, Weigang

AU - Li, Jingya

AU - Zhang, Wei

AU - Zhou, Yueyang

AU - Xie, Chuanming

AU - Luo, Yu

AU - Li, Yunfei

AU - Wang, Jingli

AU - Li, Jia

AU - Lu, Wei

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range.

AB - Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range.

KW - Cancer

KW - Cdc25 phosphatases

KW - Miltirone

UR - https://www.scopus.com/pages/publications/33144467432

U2 - 10.1016/j.bmcl.2005.12.080

DO - 10.1016/j.bmcl.2005.12.080

M3 - 文章

C2 - 16434190

AN - SCOPUS:33144467432

SN - 0960-894X

VL - 16

SP - 1905

EP - 1908

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases

摘要

联合国可持续发展目标

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