Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion

Yang Yuan; Ye Wang; Yuanyang Mu; Murong Xu; Siyi Fu; Lingkai Kong; Yanzhong Li

doi:10.1021/acs.orglett.0c02307

Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion

Yang Yuan
, Ye Wang
, Yuanyang Mu
, Murong Xu
, Siyi Fu
, Lingkai Kong^*
, Yanzhong Li^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Linyi University

科研成果: 期刊稿件 › 文章 › 同行评审

12 引用（Scopus）

摘要

A novel and efficient synthesis of aza-eight-membered ring-fused indolines has been developed. This process is realized by zinc-catalyzed C2 alkylation of indoles and subsequent base-promoted ring expansion of the newly formed six-membered ring with alkynes. Easily accessible starting materials, good functional group tolerance, and high atom economy make this procedure attractive.

源语言	英语
页（从-至）	6532-6536
页数	5
期刊	Organic Letters
卷	22
期	16
DOI	https://doi.org/10.1021/acs.orglett.0c02307
出版状态	已出版 - 21 8月 2020

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title = "Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion",

abstract = "A novel and efficient synthesis of aza-eight-membered ring-fused indolines has been developed. This process is realized by zinc-catalyzed C2 alkylation of indoles and subsequent base-promoted ring expansion of the newly formed six-membered ring with alkynes. Easily accessible starting materials, good functional group tolerance, and high atom economy make this procedure attractive.",

author = "Yang Yuan and Ye Wang and Yuanyang Mu and Murong Xu and Siyi Fu and Lingkai Kong and Yanzhong Li",

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T1 - Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion

AU - Yuan, Yang

AU - Wang, Ye

AU - Mu, Yuanyang

AU - Xu, Murong

AU - Fu, Siyi

AU - Kong, Lingkai

AU - Li, Yanzhong

PY - 2020/8/21

Y1 - 2020/8/21

N2 - A novel and efficient synthesis of aza-eight-membered ring-fused indolines has been developed. This process is realized by zinc-catalyzed C2 alkylation of indoles and subsequent base-promoted ring expansion of the newly formed six-membered ring with alkynes. Easily accessible starting materials, good functional group tolerance, and high atom economy make this procedure attractive.

AB - A novel and efficient synthesis of aza-eight-membered ring-fused indolines has been developed. This process is realized by zinc-catalyzed C2 alkylation of indoles and subsequent base-promoted ring expansion of the newly formed six-membered ring with alkynes. Easily accessible starting materials, good functional group tolerance, and high atom economy make this procedure attractive.

UR - https://www.scopus.com/pages/publications/85089787312

U2 - 10.1021/acs.orglett.0c02307

DO - 10.1021/acs.orglett.0c02307

M3 - 文章

C2 - 32806175

AN - SCOPUS:85089787312

SN - 1523-7060

VL - 22

SP - 6532

EP - 6536

JO - Organic Letters

JF - Organic Letters

IS - 16

ER -

Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion

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