Synthesis of a natural cytotoxic alkaloid artabotrine and its analogue

Hong Xia Ding; Wei Lu; Lei Xiang Yang; Hai Bo Li; Hua Bai; Xiu Mei Wu; Jun Chao Cai; Yu Zhao

Synthesis of a natural cytotoxic alkaloid artabotrine and its analogue

Hong Xia Ding^*
, Wei Lu
, Lei Xiang Yang
, Hai Bo Li
, Hua Bai
, Xiu Mei Wu
, Jun Chao Cai
, Yu Zhao

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.

源语言	英语
页（从-至）	5-8
页数	4
期刊	Chinese Chemical Letters
卷	17
期	1
出版状态	已出版 - 1月 2006
已对外发布	是

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引用此

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title = "Synthesis of a natural cytotoxic alkaloid artabotrine and its analogue",

abstract = "Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.",

keywords = "Aporphine alkaloid, Artabotrine, Cytotoxicity, Synthesis",

author = "Ding, \{Hong Xia\} and Wei Lu and Yang, \{Lei Xiang\} and Li, \{Hai Bo\} and Hua Bai and Wu, \{Xiu Mei\} and Cai, \{Jun Chao\} and Yu Zhao",

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language = "英语",

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T1 - Synthesis of a natural cytotoxic alkaloid artabotrine and its analogue

AU - Ding, Hong Xia

AU - Lu, Wei

AU - Yang, Lei Xiang

AU - Li, Hai Bo

AU - Bai, Hua

AU - Wu, Xiu Mei

AU - Cai, Jun Chao

AU - Zhao, Yu

PY - 2006/1

Y1 - 2006/1

N2 - Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.

AB - Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.

KW - Aporphine alkaloid

KW - Artabotrine

KW - Cytotoxicity

KW - Synthesis

UR - https://www.scopus.com/pages/publications/33644696608

M3 - 文章

AN - SCOPUS:33644696608

SN - 1001-8417

VL - 17

SP - 5

EP - 8

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 1

ER -