Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

Hui Peng; Lijuan Zhang; John Spires; Christian Soeller; Jadranka Travas-Sejdic

doi:10.1016/j.polymer.2007.04.029

Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

Hui Peng
, Lijuan Zhang
, John Spires
, Christian Soeller
, Jadranka Travas-Sejdic^*

^*此作品的通讯作者

The University of Auckland

科研成果: 期刊稿件 › 文章 › 同行评审

60 引用（Scopus）

摘要

The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.

源语言	英语
页（从-至）	3413-3419
页数	7
期刊	Polymer
卷	48
期	12
DOI	https://doi.org/10.1016/j.polymer.2007.04.029
出版状态	已出版 - 4 6月 2007
已对外发布	是

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title = "Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor",

abstract = "The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.",

keywords = "Conducting polymers, DNA sensor, Electropolymerisation",

author = "Hui Peng and Lijuan Zhang and John Spires and Christian Soeller and Jadranka Travas-Sejdic",

year = "2007",

month = jun,

day = "4",

doi = "10.1016/j.polymer.2007.04.029",

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TY - JOUR

T1 - Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

AU - Peng, Hui

AU - Zhang, Lijuan

AU - Spires, John

AU - Soeller, Christian

AU - Travas-Sejdic, Jadranka

PY - 2007/6/4

Y1 - 2007/6/4

N2 - The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.

AB - The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.

KW - Conducting polymers

KW - DNA sensor

KW - Electropolymerisation

UR - https://www.scopus.com/pages/publications/34248996362

U2 - 10.1016/j.polymer.2007.04.029

DO - 10.1016/j.polymer.2007.04.029

M3 - 文章

AN - SCOPUS:34248996362

SN - 0032-3861

VL - 48

SP - 3413

EP - 3419

JO - Polymer

JF - Polymer

IS - 12

ER -

Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

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