Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength

Xuhong Qian; Ping Mao; Wei Yao; Xiangfeng Guo

doi:10.1016/S0040-4039(02)00442-2

Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength

Xuhong Qian^*
, Ping Mao
, Wei Yao
, Xiangfeng Guo

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

23 引用（Scopus）

摘要

A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.

源语言	英语
页（从-至）	2995-2998
页数	4
期刊	Tetrahedron Letters
卷	43
期	16
DOI	https://doi.org/10.1016/S0040-4039(02)00442-2
出版状态	已出版 - 15 4月 2002
已对外发布	是

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abstract = "A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.",

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AU - Mao, Ping

AU - Yao, Wei

AU - Guo, Xiangfeng

PY - 2002/4/15

Y1 - 2002/4/15

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AB - A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.

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Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength

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