Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

Yan Liu; Yufang Xu; Xuhong Qian; Yi Xiao; Jianwen Liu; Liyun Shen; Junhui Li; Yuanxing Zhang

doi:10.1016/j.bmcl.2005.12.031

Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

Yan Liu
, Yufang Xu^*
, Xuhong Qian
, Yi Xiao
, Jianwen Liu
, Liyun Shen
, Junhui Li
, Yuanxing Zhang

^*此作品的通讯作者

East China University of Science and Technology
Dalian University of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

25 引用（Scopus）

摘要

Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A₂ and A₄ showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.

源语言	英语
页（从-至）	1562-1566
页数	5
期刊	Bioorganic and Medicinal Chemistry Letters
卷	16
期	6
DOI	https://doi.org/10.1016/j.bmcl.2005.12.031
出版状态	已出版 - 15 3月 2006
已对外发布	是

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title = "Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor",

abstract = "Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.",

keywords = "Evaluation, Fluorescent markers, Hypoxic cells, Solid tumor, Synthesis",

author = "Yan Liu and Yufang Xu and Xuhong Qian and Yi Xiao and Jianwen Liu and Liyun Shen and Junhui Li and Yuanxing Zhang",

year = "2006",

month = mar,

day = "15",

doi = "10.1016/j.bmcl.2005.12.031",

language = "英语",

volume = "16",

pages = "1562--1566",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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TY - JOUR

T1 - Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

AU - Liu, Yan

AU - Xu, Yufang

AU - Qian, Xuhong

AU - Xiao, Yi

AU - Liu, Jianwen

AU - Shen, Liyun

AU - Li, Junhui

AU - Zhang, Yuanxing

PY - 2006/3/15

Y1 - 2006/3/15

N2 - Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.

AB - Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.

KW - Evaluation

KW - Fluorescent markers

KW - Hypoxic cells

KW - Solid tumor

KW - Synthesis

UR - https://www.scopus.com/pages/publications/32044449150

U2 - 10.1016/j.bmcl.2005.12.031

DO - 10.1016/j.bmcl.2005.12.031

M3 - 文章

C2 - 16403630

AN - SCOPUS:32044449150

SN - 0960-894X

VL - 16

SP - 1562

EP - 1566

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

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