Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

Yu Luo; Feng Xiao; Shijing Qian; Qiaojun He; Wei Lu; Bo Yang

doi:10.1039/c1md00105a

Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

Yu Luo
, Feng Xiao
, Shijing Qian
, Qiaojun He
, Wei Lu^*
, Bo Yang

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Zhejiang University

科研成果: 期刊稿件 › 文章 › 同行评审

7 引用（Scopus）

摘要

A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

源语言	英语
页（从-至）	1054-1057
页数	4
期刊	MedChemComm
卷	2
期	11
DOI	https://doi.org/10.1039/c1md00105a
出版状态	已出版 - 11月 2011

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10.1039/c1md00105a

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title = "Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents",

abstract = "A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.",

author = "Yu Luo and Feng Xiao and Shijing Qian and Qiaojun He and Wei Lu and Bo Yang",

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AU - Xiao, Feng

AU - Qian, Shijing

AU - He, Qiaojun

AU - Lu, Wei

AU - Yang, Bo

PY - 2011/11

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N2 - A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

AB - A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

UR - https://www.scopus.com/pages/publications/80455163194

U2 - 10.1039/c1md00105a

DO - 10.1039/c1md00105a

M3 - 文章

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SN - 2040-2503

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Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

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