TY - JOUR
T1 - Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines
AU - Ding, Hongxia
AU - Lu, Wei
AU - Li, Haibo
AU - Yang, Leixiang
AU - Zhang, Qijun
AU - Zhou, Changxin
AU - Wu, Xiumei
AU - Baudoin, Olivier
AU - Cai, Junchao
AU - Guéritte, Françoise
AU - Zhao, Yu
PY - 2005
Y1 - 2005
N2 - Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10-6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.
AB - Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10-6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.
UR - https://www.scopus.com/pages/publications/26044436557
U2 - 10.1002/cbdv.200590092
DO - 10.1002/cbdv.200590092
M3 - 文章
C2 - 17193204
AN - SCOPUS:26044436557
SN - 1612-1872
VL - 2
SP - 1217
EP - 1231
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 9
ER -