Synthesis and antitumor activity of tanshinone analogues

Haji Akber Aisa; Wei Lu; Jun Chao Cai

doi:10.1002/cjoc.20030210703

Synthesis and antitumor activity of tanshinone analogues

Haji Akber Aisa^*
, Wei Lu
, Jun Chao Cai

^*此作品的通讯作者

Xinjiang Technical Institute of Physics and Chemistry
CAS - Shanghai Institute of Materia Medica

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.

源语言	英语
页（从-至）	720-722
页数	3
期刊	Chinese Journal of Chemistry
卷	21
期	7
DOI	https://doi.org/10.1002/cjoc.20030210703
出版状态	已出版 - 7月 2003
已对外发布	是

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title = "Synthesis and antitumor activity of tanshinone analogues",

abstract = "8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.",

keywords = "Analogues, Synthesis, Tanshinone",

author = "Aisa, \{Haji Akber\} and Wei Lu and Cai, \{Jun Chao\}",

year = "2003",

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doi = "10.1002/cjoc.20030210703",

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T1 - Synthesis and antitumor activity of tanshinone analogues

AU - Aisa, Haji Akber

AU - Lu, Wei

AU - Cai, Jun Chao

PY - 2003/7

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N2 - 8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.

AB - 8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.

KW - Analogues

KW - Synthesis

KW - Tanshinone

UR - https://www.scopus.com/pages/publications/33748042967

U2 - 10.1002/cjoc.20030210703

DO - 10.1002/cjoc.20030210703

M3 - 文章

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SN - 1001-604X

VL - 21

SP - 720

EP - 722

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 7

ER -

Synthesis and antitumor activity of tanshinone analogues

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