Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety

Yi Liu; Wei Lu; Qing Chuan Liu; Zheng Ming Huang; Guang Yi Liang; Bi Xue Xu

doi:10.16438/j.0513-4870.2017-0059

Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety

Yi Liu
, Wei Lu
, Qing Chuan Liu
, Zheng Ming Huang
, Guang Yi Liang
, Bi Xue Xu

Guizhou University
Guizhou Medical University
Chinese Academy of Sciences
PLA No. 302 Hospital
Guizhou University of Traditional Chinese Medicine

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

In this study, eleven containing gallic acid moiety derivatives of Matijin-Su (MTS) were synthesized and evaluated for their anti-HBV activities in HepG2 2.2.15 cells in an effort to find novel effective anti-hepatitis B virus (HBV) agents. Compounds 5c, 6c and 6d exhibited significant anti-HBV activity with IC₅₀ values of 6.12, 8.44 and 9.86 μmol-L^-1, respectively. Incorporation of gallic acid moiety into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.

源语言	英语
页（从-至）	1140-1145
页数	6
期刊	Yaoxue Xuebao
卷	52
期	7
DOI	https://doi.org/10.16438/j.0513-4870.2017-0059
出版状态	已出版 - 12 7月 2017
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.16438/j.0513-4870.2017-0059

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@article{f8517e7b5411402285999c39e7553b76,

title = "Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety",

abstract = "In this study, eleven containing gallic acid moiety derivatives of Matijin-Su (MTS) were synthesized and evaluated for their anti-HBV activities in HepG2 2.2.15 cells in an effort to find novel effective anti-hepatitis B virus (HBV) agents. Compounds 5c, 6c and 6d exhibited significant anti-HBV activity with IC50 values of 6.12, 8.44 and 9.86 μmol-L-1, respectively. Incorporation of gallic acid moiety into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.",

keywords = "Biological activity, Derivative of Matijin-Su, Hepatitis B virus, Synthesis",

author = "Yi Liu and Wei Lu and Liu, \{Qing Chuan\} and Huang, \{Zheng Ming\} and Liang, \{Guang Yi\} and Xu, \{Bi Xue\}",

year = "2017",

month = jul,

day = "12",

doi = "10.16438/j.0513-4870.2017-0059",

language = "英语",

volume = "52",

pages = "1140--1145",

journal = "Yaoxue Xuebao",

issn = "0513-4870",

publisher = "Chinese Pharmaceutical Association",

number = "7",

}

TY - JOUR

T1 - Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety

AU - Liu, Yi

AU - Lu, Wei

AU - Liu, Qing Chuan

AU - Huang, Zheng Ming

AU - Liang, Guang Yi

AU - Xu, Bi Xue

PY - 2017/7/12

Y1 - 2017/7/12

N2 - In this study, eleven containing gallic acid moiety derivatives of Matijin-Su (MTS) were synthesized and evaluated for their anti-HBV activities in HepG2 2.2.15 cells in an effort to find novel effective anti-hepatitis B virus (HBV) agents. Compounds 5c, 6c and 6d exhibited significant anti-HBV activity with IC50 values of 6.12, 8.44 and 9.86 μmol-L-1, respectively. Incorporation of gallic acid moiety into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.

AB - In this study, eleven containing gallic acid moiety derivatives of Matijin-Su (MTS) were synthesized and evaluated for their anti-HBV activities in HepG2 2.2.15 cells in an effort to find novel effective anti-hepatitis B virus (HBV) agents. Compounds 5c, 6c and 6d exhibited significant anti-HBV activity with IC50 values of 6.12, 8.44 and 9.86 μmol-L-1, respectively. Incorporation of gallic acid moiety into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.

KW - Biological activity

KW - Derivative of Matijin-Su

KW - Hepatitis B virus

KW - Synthesis

UR - https://www.scopus.com/pages/publications/85029153383

U2 - 10.16438/j.0513-4870.2017-0059

DO - 10.16438/j.0513-4870.2017-0059

M3 - 文章

AN - SCOPUS:85029153383

SN - 0513-4870

VL - 52

SP - 1140

EP - 1145

JO - Yaoxue Xuebao

JF - Yaoxue Xuebao

IS - 7

ER -

Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety

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