Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles

Jinlou Gu; Shasha Su; Yongsheng Li; Qianjun He; Jiaying Zhong; Jianlin Shi

doi:10.1021/jz101483u

Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles

Jinlou Gu^*
, Shasha Su
, Yongsheng Li
, Qianjun He
, Jiaying Zhong
, Jianlin Shi

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

80 引用（Scopus）

摘要

High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

源语言	英语
页（从-至）	3446-3450
页数	5
期刊	Journal of Physical Chemistry Letters
卷	1
期	24
DOI	https://doi.org/10.1021/jz101483u
出版状态	已出版 - 16 12月 2010
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1021/jz101483u

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title = "Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles",

abstract = "High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.",

author = "Jinlou Gu and Shasha Su and Yongsheng Li and Qianjun He and Jiaying Zhong and Jianlin Shi",

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AU - Gu, Jinlou

AU - Su, Shasha

AU - Li, Yongsheng

AU - He, Qianjun

AU - Zhong, Jiaying

AU - Shi, Jianlin

PY - 2010/12/16

Y1 - 2010/12/16

N2 - High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

AB - High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

UR - https://www.scopus.com/pages/publications/78650326921

U2 - 10.1021/jz101483u

DO - 10.1021/jz101483u

M3 - 文章

AN - SCOPUS:78650326921

SN - 1948-7185

VL - 1

SP - 3446

EP - 3450

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

IS - 24

ER -

Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles

摘要

联合国可持续发展目标

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