Stereospecific synthesis of highly functionalized benzo[3.1.0]bicycloalkanes via multistep cascade reactions

Jian Bo Zhu; Hao Chen; Lijia Wang; Yong Tang

doi:10.1039/c4qo00134f

Stereospecific synthesis of highly functionalized benzo[3.1.0]bicycloalkanes via multistep cascade reactions

Jian Bo Zhu
, Hao Chen
, Lijia Wang
, Yong Tang^*

^*此作品的通讯作者

CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

A facile approach for the synthesis of benzo[3.1.0]bicycloalkanes via alkylation/cyclopropanation cascade reactions of benzyl bromide with triphenylphosphonium bromide has been developed. By elaborate designing of starting materials, this multistep cyclization proceeded smoothly with a wide range of substrates, providing the benzo[3.1.0]bicycloalkanes in 52-90% yields with exclusive diastereoselectivity.

源语言	英语
页（从-至）	965-968
页数	4
期刊	Organic Chemistry Frontiers
卷	1
期	8
DOI	https://doi.org/10.1039/c4qo00134f
出版状态	已出版 - 1 10月 2014
已对外发布	是

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abstract = "A facile approach for the synthesis of benzo[3.1.0]bicycloalkanes via alkylation/cyclopropanation cascade reactions of benzyl bromide with triphenylphosphonium bromide has been developed. By elaborate designing of starting materials, this multistep cyclization proceeded smoothly with a wide range of substrates, providing the benzo[3.1.0]bicycloalkanes in 52-90\% yields with exclusive diastereoselectivity.",

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AU - Zhu, Jian Bo

AU - Chen, Hao

AU - Wang, Lijia

AU - Tang, Yong

PY - 2014/10/1

Y1 - 2014/10/1

N2 - A facile approach for the synthesis of benzo[3.1.0]bicycloalkanes via alkylation/cyclopropanation cascade reactions of benzyl bromide with triphenylphosphonium bromide has been developed. By elaborate designing of starting materials, this multistep cyclization proceeded smoothly with a wide range of substrates, providing the benzo[3.1.0]bicycloalkanes in 52-90% yields with exclusive diastereoselectivity.

AB - A facile approach for the synthesis of benzo[3.1.0]bicycloalkanes via alkylation/cyclopropanation cascade reactions of benzyl bromide with triphenylphosphonium bromide has been developed. By elaborate designing of starting materials, this multistep cyclization proceeded smoothly with a wide range of substrates, providing the benzo[3.1.0]bicycloalkanes in 52-90% yields with exclusive diastereoselectivity.

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Stereospecific synthesis of highly functionalized benzo[3.1.0]bicycloalkanes via multistep cascade reactions

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