Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Min Zhu; Yanyan Yu; Junfeng Zhu; Yao Zhou; Gaoxing Su; Hongyan Zhu; Yong Chen; Mingkai Liu

doi:10.1039/d0cc03425h

Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Min Zhu
, Yanyan Yu^*
, Junfeng Zhu
, Yao Zhou
, Gaoxing Su
, Hongyan Zhu
, Yong Chen
, Mingkai Liu

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

3 引用（Scopus）

摘要

Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

源语言	英语
页（从-至）	8599-8602
页数	4
期刊	Chemical Communications
卷	56
期	61
DOI	https://doi.org/10.1039/d0cc03425h
出版状态	已出版 - 7 8月 2020
已对外发布	是

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abstract = "Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.",

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AU - Zhu, Min

AU - Yu, Yanyan

AU - Zhu, Junfeng

AU - Zhou, Yao

AU - Su, Gaoxing

AU - Zhu, Hongyan

AU - Chen, Yong

AU - Liu, Mingkai

PY - 2020/8/7

Y1 - 2020/8/7

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AB - Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

UR - https://www.scopus.com/pages/publications/85089127271

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Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

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