Silver-catalyzed cascade reaction of o-aminoaryl compounds with alkynes: An aniline mediated synthesis of 2-substituted quinolines

Hongfeng Li; Chengyu Wang; He Huang; Xiaolei Xu; Yanzhong Li

doi:10.1016/j.tetlet.2010.12.102

Silver-catalyzed cascade reaction of o-aminoaryl compounds with alkynes: An aniline mediated synthesis of 2-substituted quinolines

Hongfeng Li
, Chengyu Wang
, He Huang
, Xiaolei Xu
, Yanzhong Li^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

50 引用（Scopus）

摘要

An efficient silver-catalyzed, aniline mediated cascade hydroamination/cycloaddition of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones with alkynes for the synthesis of 2- or 2,4-substituted quinolines is reported. The reactions proceed with high regioselectivity to afford mono- or disubstituted quinoline derivatives in good to high yields using AgOTf as the catalyst in the air.

源语言	英语
页（从-至）	1108-1111
页数	4
期刊	Tetrahedron Letters
卷	52
期	10
DOI	https://doi.org/10.1016/j.tetlet.2010.12.102
出版状态	已出版 - 9 3月 2011

访问文件

10.1016/j.tetlet.2010.12.102

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{b326668f10e44336bc503338a80ce3e0,

title = "Silver-catalyzed cascade reaction of o-aminoaryl compounds with alkynes: An aniline mediated synthesis of 2-substituted quinolines",

abstract = "An efficient silver-catalyzed, aniline mediated cascade hydroamination/cycloaddition of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones with alkynes for the synthesis of 2- or 2,4-substituted quinolines is reported. The reactions proceed with high regioselectivity to afford mono- or disubstituted quinoline derivatives in good to high yields using AgOTf as the catalyst in the air.",

keywords = "Cascade Reaction, Hydroamination, Quinolines, Silver catalysis",

author = "Hongfeng Li and Chengyu Wang and He Huang and Xiaolei Xu and Yanzhong Li",

year = "2011",

month = mar,

day = "9",

doi = "10.1016/j.tetlet.2010.12.102",

language = "英语",

volume = "52",

pages = "1108--1111",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "10",

}

TY - JOUR

T1 - Silver-catalyzed cascade reaction of o-aminoaryl compounds with alkynes

T2 - An aniline mediated synthesis of 2-substituted quinolines

AU - Li, Hongfeng

AU - Wang, Chengyu

AU - Huang, He

AU - Xu, Xiaolei

AU - Li, Yanzhong

PY - 2011/3/9

Y1 - 2011/3/9

N2 - An efficient silver-catalyzed, aniline mediated cascade hydroamination/cycloaddition of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones with alkynes for the synthesis of 2- or 2,4-substituted quinolines is reported. The reactions proceed with high regioselectivity to afford mono- or disubstituted quinoline derivatives in good to high yields using AgOTf as the catalyst in the air.

AB - An efficient silver-catalyzed, aniline mediated cascade hydroamination/cycloaddition of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones with alkynes for the synthesis of 2- or 2,4-substituted quinolines is reported. The reactions proceed with high regioselectivity to afford mono- or disubstituted quinoline derivatives in good to high yields using AgOTf as the catalyst in the air.

KW - Cascade Reaction

KW - Hydroamination

KW - Quinolines

KW - Silver catalysis

UR - https://www.scopus.com/pages/publications/79551680934

U2 - 10.1016/j.tetlet.2010.12.102

DO - 10.1016/j.tetlet.2010.12.102

M3 - 文章

AN - SCOPUS:79551680934

SN - 0040-4039

VL - 52

SP - 1108

EP - 1111

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 10

ER -

Silver-catalyzed cascade reaction of o-aminoaryl compounds with alkynes: An aniline mediated synthesis of 2-substituted quinolines

摘要

访问文件

其它文件与链接

指纹

引用此