Silencing of E6/E7 expression in cervical cancer stem- like cells

Wenyi Gu; Nigel McMillan; Chengzhong Yu

doi:10.1007/978-1-4939-2013-6_12

Silencing of E6/E7 expression in cervical cancer stem- like cells

Wenyi Gu^*
, Nigel McMillan
, Chengzhong Yu

^*此作品的通讯作者

科研成果: 书/报告/会议事项章节 › 章节 › 同行评审

1 引用（Scopus）

摘要

Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.

源语言	英语
主期刊名	Cervical Cancer
主期刊副标题	Methods and Protocols
出版商	Springer New York
页	173-182
页数	10
ISBN（电子版）	9781493920136
ISBN（印刷版）	9781493920129
DOI	https://doi.org/10.1007/978-1-4939-2013-6_12
出版状态	已出版 - 27 10月 2014
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

访问文件

10.1007/978-1-4939-2013-6_12

其它文件与链接

链接到 Scopus 的出版物

引用此

@inbook{87019657f9724eeebea65140ad126e75,

title = "Silencing of E6/E7 expression in cervical cancer stem- like cells",

abstract = "Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.",

keywords = "Cancer stem cells, Gene silence, HPV E6/E7, RNAi",

author = "Wenyi Gu and Nigel McMillan and Chengzhong Yu",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2015. All rights are reserved.",

year = "2014",

month = oct,

day = "27",

doi = "10.1007/978-1-4939-2013-6\_12",

language = "英语",

isbn = "9781493920129",

pages = "173--182",

booktitle = "Cervical Cancer",

publisher = "Springer New York",

address = "美国",

}

TY - CHAP

T1 - Silencing of E6/E7 expression in cervical cancer stem- like cells

AU - Gu, Wenyi

AU - McMillan, Nigel

AU - Yu, Chengzhong

N1 - Publisher Copyright: © Springer Science+Business Media New York 2015. All rights are reserved.

PY - 2014/10/27

Y1 - 2014/10/27

N2 - Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.

AB - Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.

KW - Cancer stem cells

KW - Gene silence

KW - HPV E6/E7

KW - RNAi

UR - https://www.scopus.com/pages/publications/84921744522

U2 - 10.1007/978-1-4939-2013-6_12

DO - 10.1007/978-1-4939-2013-6_12

M3 - 章节

AN - SCOPUS:84921744522

SN - 9781493920129

SP - 173

EP - 182

BT - Cervical Cancer

PB - Springer New York

ER -

Silencing of E6/E7 expression in cervical cancer stem- like cells

摘要

联合国可持续发展目标

访问文件

其它文件与链接

指纹

引用此