Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

Bin Wang; Rizhao Pan; Weiping Zhu; Yufang Xu; Ye Tian; Masayuki Endo; Hiroshi Sugiyama; Yangyang Yang; Xuhong Qian

doi:10.1039/d0sm01817a

Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

Bin Wang
, Rizhao Pan
, Weiping Zhu
, Yufang Xu
, Ye Tian
, Masayuki Endo
, Hiroshi Sugiyama
, Yangyang Yang^*
, Xuhong Qian

^*此作品的通讯作者

East China University of Science and Technology
Nanjing University
Kyoto University

科研成果: 期刊稿件 › 文章 › 同行评审

13 引用（Scopus）

摘要

A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.

源语言	英语
页（从-至）	1184-1188
页数	5
期刊	Soft Matter
卷	17
期	5
DOI	https://doi.org/10.1039/d0sm01817a
出版状态	已出版 - 7 2月 2021
已对外发布	是

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abstract = "A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.",

author = "Bin Wang and Rizhao Pan and Weiping Zhu and Yufang Xu and Ye Tian and Masayuki Endo and Hiroshi Sugiyama and Yangyang Yang and Xuhong Qian",

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AU - Wang, Bin

AU - Pan, Rizhao

AU - Zhu, Weiping

AU - Xu, Yufang

AU - Tian, Ye

AU - Endo, Masayuki

AU - Sugiyama, Hiroshi

AU - Yang, Yangyang

AU - Qian, Xuhong

PY - 2021/2/7

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AB - A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.

UR - https://www.scopus.com/pages/publications/85101445641

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Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

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