Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: A facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

Lai Wei; Lu Liu; Junliang Zhang

doi:10.1039/c4ob01057d

Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: A facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

Lai Wei
, Lu Liu^*
, Junliang Zhang

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

20 引用（Scopus）

摘要

A facile technique involving a novel Lewis-acid-catalyzed tandem selective ring-opening of oxirane and Friedel-Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed. The developed protocol affords functionalized [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines in up to 95% yield. This journal is

源语言	英语
页（从-至）	6869-6877
页数	9
期刊	Organic and Biomolecular Chemistry
卷	12
期	35
DOI	https://doi.org/10.1039/c4ob01057d
出版状态	已出版 - 21 9月 2014

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AU - Liu, Lu

AU - Zhang, Junliang

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AB - A facile technique involving a novel Lewis-acid-catalyzed tandem selective ring-opening of oxirane and Friedel-Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed. The developed protocol affords functionalized [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines in up to 95% yield. This journal is

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Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: A facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

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