Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

Haihong He; Tingting He; Ziqian Zhang; Xiu Xu; Huibin Yang; Xuhong Qian; Youjun Yang

doi:10.1016/j.cclet.2018.08.019

Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

Haihong He
, Tingting He
, Ziqian Zhang
, Xiu Xu
, Huibin Yang
, Xuhong Qian
, Youjun Yang^*

^*此作品的通讯作者

East China University of Science and Technology
Guangxi University of Chinese Medicine
Sinochem

科研成果: 期刊稿件 › 文章 › 同行评审

24 引用（Scopus）

摘要

Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).

源语言	英语
页（从-至）	1497-1499
页数	3
期刊	Chinese Chemical Letters
卷	29
期	10
DOI	https://doi.org/10.1016/j.cclet.2018.08.019
出版状态	已出版 - 10月 2018
已对外发布	是

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title = "Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor",

abstract = "Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).",

keywords = "Antimicrobial, NO donor, Photo-calibrate, Photo-trigger, Platelet aggregation inhibition",

author = "Haihong He and Tingting He and Ziqian Zhang and Xiu Xu and Huibin Yang and Xuhong Qian and Youjun Yang",

note = "Publisher Copyright: {\textcopyright} 2018 The Author",

year = "2018",

month = oct,

doi = "10.1016/j.cclet.2018.08.019",

language = "英语",

volume = "29",

pages = "1497--1499",

journal = "Chinese Chemical Letters",

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TY - JOUR

T1 - Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

AU - He, Haihong

AU - He, Tingting

AU - Zhang, Ziqian

AU - Xu, Xiu

AU - Yang, Huibin

AU - Qian, Xuhong

AU - Yang, Youjun

PY - 2018/10

Y1 - 2018/10

N2 - Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).

AB - Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).

KW - Antimicrobial

KW - NO donor

KW - Photo-calibrate

KW - Photo-trigger

KW - Platelet aggregation inhibition

UR - https://www.scopus.com/pages/publications/85053107155

U2 - 10.1016/j.cclet.2018.08.019

DO - 10.1016/j.cclet.2018.08.019

M3 - 文章

AN - SCOPUS:85053107155

SN - 1001-8417

VL - 29

SP - 1497

EP - 1499

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 10

ER -

Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

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