Rhodium-Catalyzed Sequential Cycloisomerization/Aldol Addition of Cyclopropene Carboxylic Acids with Isatins

Dan Zhang; Xin Wang; Mengchu Zhang; Wenhao Hu

doi:10.1021/acs.orglett.0c01957

Rhodium-Catalyzed Sequential Cycloisomerization/Aldol Addition of Cyclopropene Carboxylic Acids with Isatins

Dan Zhang^*
, Xin Wang
, Mengchu Zhang
, Wenhao Hu^*

^*此作品的通讯作者

Sun Yat-Sen University

科研成果: 期刊稿件 › 文章 › 同行评审

14 引用（Scopus）

摘要

A unique, rhodium-catalyzed reaction of cyclopropene carboxylic acids with isatins has been developed, which takes place through a trapping process of transient cyclic carboxylic oxonium ylides. This reaction tolerates a wide variety of cyclopropene carboxylic acids and N-protected or unprotected isatins and represents a new, direct strategy to access valuable γ-substituted γ-butenolide architectures containing an oxindole moiety in very high yields under mild reaction conditions.

源语言	英语
页（从-至）	5600-5604
页数	5
期刊	Organic Letters
卷	22
期	14
DOI	https://doi.org/10.1021/acs.orglett.0c01957
出版状态	已出版 - 17 7月 2020
已对外发布	是

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abstract = "A unique, rhodium-catalyzed reaction of cyclopropene carboxylic acids with isatins has been developed, which takes place through a trapping process of transient cyclic carboxylic oxonium ylides. This reaction tolerates a wide variety of cyclopropene carboxylic acids and N-protected or unprotected isatins and represents a new, direct strategy to access valuable γ-substituted γ-butenolide architectures containing an oxindole moiety in very high yields under mild reaction conditions.",

author = "Dan Zhang and Xin Wang and Mengchu Zhang and Wenhao Hu",

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AU - Zhang, Dan

AU - Wang, Xin

AU - Zhang, Mengchu

AU - Hu, Wenhao

PY - 2020/7/17

Y1 - 2020/7/17

N2 - A unique, rhodium-catalyzed reaction of cyclopropene carboxylic acids with isatins has been developed, which takes place through a trapping process of transient cyclic carboxylic oxonium ylides. This reaction tolerates a wide variety of cyclopropene carboxylic acids and N-protected or unprotected isatins and represents a new, direct strategy to access valuable γ-substituted γ-butenolide architectures containing an oxindole moiety in very high yields under mild reaction conditions.

AB - A unique, rhodium-catalyzed reaction of cyclopropene carboxylic acids with isatins has been developed, which takes place through a trapping process of transient cyclic carboxylic oxonium ylides. This reaction tolerates a wide variety of cyclopropene carboxylic acids and N-protected or unprotected isatins and represents a new, direct strategy to access valuable γ-substituted γ-butenolide architectures containing an oxindole moiety in very high yields under mild reaction conditions.

UR - https://www.scopus.com/pages/publications/85088148270

U2 - 10.1021/acs.orglett.0c01957

DO - 10.1021/acs.orglett.0c01957

M3 - 文章

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AN - SCOPUS:85088148270

SN - 1523-7060

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SP - 5600

EP - 5604

JO - Organic Letters

JF - Organic Letters

IS - 14

ER -

Rhodium-Catalyzed Sequential Cycloisomerization/Aldol Addition of Cyclopropene Carboxylic Acids with Isatins

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