Rhodium-Catalyzed [2 + 1] Annulation of Alkynyl Acylsilanes with Diazoacetates: Access to Tetrasubstituted Epoxides

Guang Hui Li; Xue Di Zhao; Shengchao Yang; Lijia Wang; Lu Liu

doi:10.1021/acs.orglett.6c01615

Rhodium-Catalyzed [2 + 1] Annulation of Alkynyl Acylsilanes with Diazoacetates: Access to Tetrasubstituted Epoxides

Guang Hui Li
, Xue Di Zhao
, Shengchao Yang^*
, Lijia Wang^*
, Lu Liu^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Shihezi University

科研成果: 期刊稿件 › 快报 › 同行评审

摘要

A mild and practical Rh₂(OAc)₄-catalyzed [2 + 1] annulation of alkynyl acylsilanes with aryl diazoacetates has been developed, affording a wide range of functionalized tetrasubstituted epoxides in high yields. This method features broad substrate scope, excellent functional group compatibility, and gram-scale scalability. The synthetic utility of the resulting epoxides is also demonstrated by diverse chemical transformations.

源语言	英语
页（从-至）	7185-7190
页数	6
期刊	Organic Letters
卷	28
期	23
DOI	https://doi.org/10.1021/acs.orglett.6c01615
出版状态	已出版 - 12 6月 2026

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10.1021/acs.orglett.6c01615

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abstract = "A mild and practical Rh2(OAc)4-catalyzed [2 + 1] annulation of alkynyl acylsilanes with aryl diazoacetates has been developed, affording a wide range of functionalized tetrasubstituted epoxides in high yields. This method features broad substrate scope, excellent functional group compatibility, and gram-scale scalability. The synthetic utility of the resulting epoxides is also demonstrated by diverse chemical transformations.",

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T1 - Rhodium-Catalyzed [2 + 1] Annulation of Alkynyl Acylsilanes with Diazoacetates

T2 - Access to Tetrasubstituted Epoxides

AU - Li, Guang Hui

AU - Zhao, Xue Di

AU - Yang, Shengchao

AU - Wang, Lijia

AU - Liu, Lu

PY - 2026/6/12

Y1 - 2026/6/12

N2 - A mild and practical Rh2(OAc)4-catalyzed [2 + 1] annulation of alkynyl acylsilanes with aryl diazoacetates has been developed, affording a wide range of functionalized tetrasubstituted epoxides in high yields. This method features broad substrate scope, excellent functional group compatibility, and gram-scale scalability. The synthetic utility of the resulting epoxides is also demonstrated by diverse chemical transformations.

AB - A mild and practical Rh2(OAc)4-catalyzed [2 + 1] annulation of alkynyl acylsilanes with aryl diazoacetates has been developed, affording a wide range of functionalized tetrasubstituted epoxides in high yields. This method features broad substrate scope, excellent functional group compatibility, and gram-scale scalability. The synthetic utility of the resulting epoxides is also demonstrated by diverse chemical transformations.

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DO - 10.1021/acs.orglett.6c01615

M3 - 快报

AN - SCOPUS:105041619717

SN - 1523-7060

VL - 28

SP - 7185

EP - 7190

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Rhodium-Catalyzed [2 + 1] Annulation of Alkynyl Acylsilanes with Diazoacetates: Access to Tetrasubstituted Epoxides

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