Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins

Guang Hui Li; Xin Yu Huang; Jun Xi Lv; Xue Di Zhao; Shengchao Yang; Lu Liu

doi:10.1002/ejoc.202400899

Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins

Guang Hui Li
, Xin Yu Huang
, Jun Xi Lv
, Xue Di Zhao
, Shengchao Yang^*
, Lu Liu^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Shihezi University

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

Herein, we describe a Rh₂(OAc)₄-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.

源语言	英语
文章编号	e202400899
期刊	European Journal of Organic Chemistry
卷	27
期	48
DOI	https://doi.org/10.1002/ejoc.202400899
出版状态	已出版 - 23 12月 2024

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@article{13acf51be9da4f8ebc914e6b2e23d16c,

title = "Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins",

abstract = "Herein, we describe a Rh2(OAc)4-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.",

keywords = "2-oxopyridinyl, 2-trimethylsiloxy-pyridine, gem-difluoro olefin, rhodium-catalyzed, trifluoromethyl carbene",

author = "Li, \{Guang Hui\} and Huang, \{Xin Yu\} and Lv, \{Jun Xi\} and Zhao, \{Xue Di\} and Shengchao Yang and Lu Liu",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley-VCH GmbH.",

year = "2024",

month = dec,

day = "23",

doi = "10.1002/ejoc.202400899",

language = "英语",

volume = "27",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-VCH Verlag",

number = "48",

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TY - JOUR

T1 - Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane

T2 - An Approach to Tetrasubstituted gem-Difluoro Olefins

AU - Li, Guang Hui

AU - Huang, Xin Yu

AU - Lv, Jun Xi

AU - Zhao, Xue Di

AU - Yang, Shengchao

AU - Liu, Lu

PY - 2024/12/23

Y1 - 2024/12/23

N2 - Herein, we describe a Rh2(OAc)4-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.

AB - Herein, we describe a Rh2(OAc)4-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.

KW - 2-oxopyridinyl

KW - 2-trimethylsiloxy-pyridine

KW - gem-difluoro olefin

KW - rhodium-catalyzed

KW - trifluoromethyl carbene

UR - https://www.scopus.com/pages/publications/85211205238

U2 - 10.1002/ejoc.202400899

DO - 10.1002/ejoc.202400899

M3 - 文章

AN - SCOPUS:85211205238

SN - 1434-193X

VL - 27

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 48

M1 - e202400899

ER -

Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins

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