Recent advances in the total synthesis of gracilamine

Gracilamine belongs to the Amaryllidaceae alkaloid group and has a unique five-ring skeleton. Its scarcity in plants limits biological studies on it. A number of synthetic chemists have carried out the total synthesis of gracilamine in the past few years. This review will summarize the synthetic studies of gracilamine, and hopes to bring new inspiration to the research of Amaryllidaceae alkaloids.