Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

Shiliang He; Mengmeng Liu; Fangfei Yin; Jiangbo Liu; Zhilei Ge; Fan Li; Min Li; Jiye Shi; Lihua Wang; Xiuhai Mao; Xiaolei Zuo; Qian Li

doi:10.1039/d1cc00266j

Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

Shiliang He
, Mengmeng Liu
, Fangfei Yin
, Jiangbo Liu
, Zhilei Ge
, Fan Li
, Min Li
, Jiye Shi
, Lihua Wang
, Xiuhai Mao
, Xiaolei Zuo
, Qian Li^*

^*此作品的通讯作者

化学与分子工程学院

Shanghai Jiao Tong University
Chinese Academy of Sciences

科研成果: 期刊稿件 › 文章 › 同行评审

13 引用（Scopus）

摘要

The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H⁺-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.

源语言	英语
页（从-至）	3247-3250
页数	4
期刊	Chemical Communications
卷	57
期	26
DOI	https://doi.org/10.1039/d1cc00266j
出版状态	已出版 - 4 4月 2021

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title = "Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations",

abstract = "The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H+-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.",

author = "Shiliang He and Mengmeng Liu and Fangfei Yin and Jiangbo Liu and Zhilei Ge and Fan Li and Min Li and Jiye Shi and Lihua Wang and Xiuhai Mao and Xiaolei Zuo and Qian Li",

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doi = "10.1039/d1cc00266j",

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T1 - Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

AU - He, Shiliang

AU - Liu, Mengmeng

AU - Yin, Fangfei

AU - Liu, Jiangbo

AU - Ge, Zhilei

AU - Li, Fan

AU - Li, Min

AU - Shi, Jiye

AU - Wang, Lihua

AU - Mao, Xiuhai

AU - Zuo, Xiaolei

AU - Li, Qian

PY - 2021/4/4

Y1 - 2021/4/4

N2 - The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H+-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.

AB - The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H+-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.

UR - https://www.scopus.com/pages/publications/85103480686

U2 - 10.1039/d1cc00266j

DO - 10.1039/d1cc00266j

M3 - 文章

C2 - 33646233

AN - SCOPUS:85103480686

SN - 1359-7345

VL - 57

SP - 3247

EP - 3250

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

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