Preparation of hierarchically porous MBG/CPC scaffold and its performance on drug loading and release

Hierarchically composite scaffold (MBG/CPC) was successfully prepared by loading of mesoporous bioactive glasses (MBG) into macroporous calcium phosphate cement (CPC) with simply centrifuging method. It is revealed that MBG loading capacity on CPC and the BET surface area of MBG/CPC can reach 47.2% and 100.1 m²/g, respectively. In contrast, almost no MBG loading is detected by using traditional impregnation route. Drug loading and releasing tests show that DOX loading capacity on hierarchically composite scaffold MBG/CPC is 46 mg/g, which is 11.5 times of that on pure CPC. Importantly, a sustained drug release in vitro performance is presented on MBG/CPC.