PPAR-γ and aging: One link through klotho?

Ruihua Zhang; Feng Zheng

doi:10.1038/ki.2008.382

PPAR-γ and aging: One link through klotho?

Ruihua Zhang
, Feng Zheng^*

^*此作品的通讯作者

Icahn School of Medicine at Mount Sinai

科研成果: 期刊稿件 › 评论/辩论

51 引用（Scopus）

摘要

PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-γ may prompt further exploration of the role and mechanism of action of PPAR-γ in aging and bone diseases.

源语言	英语
页（从-至）	702-704
页数	3
期刊	Kidney International
卷	74
期	6
DOI	https://doi.org/10.1038/ki.2008.382
出版状态	已出版 - 9月 2008
已对外发布	是

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title = "PPAR-γ and aging: One link through klotho?",

abstract = "PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-γ may prompt further exploration of the role and mechanism of action of PPAR-γ in aging and bone diseases.",

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AB - PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression. Klotho is predominantly expressed by the kidney and functions at the tubule and in the circulation as an anti-aging factor and a hormone participating in mineral metabolism. The finding that klotho is upregulated by PPAR-γ may prompt further exploration of the role and mechanism of action of PPAR-γ in aging and bone diseases.

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M3 - 评论/辩论

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PPAR-γ and aging: One link through klotho?

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