Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies

Yiyun Cheng; Mingzhong Li; Tongwen Xu

doi:10.1016/j.ejmech.2007.09.030

Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies

Yiyun Cheng^*
, Mingzhong Li
, Tongwen Xu

^*此作品的通讯作者

University of Science and Technology of China

科研成果: 期刊稿件 › 文章 › 同行评审

73 引用（Scopus）

摘要

Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT.

源语言	英语
页（从-至）	1791-1795
页数	5
期刊	European Journal of Medicinal Chemistry
卷	43
期	8
DOI	https://doi.org/10.1016/j.ejmech.2007.09.030
出版状态	已出版 - 8月 2008
已对外发布	是

联合国可持续发展目标

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title = "Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies",

abstract = "Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT.",

keywords = "Anti-cancer drugs, Camptothecin, Drug carrier, PAMAM, Poly(amidoamine) dendrimers, Solubility",

author = "Yiyun Cheng and Mingzhong Li and Tongwen Xu",

year = "2008",

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doi = "10.1016/j.ejmech.2007.09.030",

language = "英语",

volume = "43",

pages = "1791--1795",

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T1 - Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies

AU - Cheng, Yiyun

AU - Li, Mingzhong

AU - Xu, Tongwen

PY - 2008/8

Y1 - 2008/8

N2 - Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT.

AB - Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT.

KW - Anti-cancer drugs

KW - Camptothecin

KW - Drug carrier

KW - PAMAM

KW - Poly(amidoamine) dendrimers

KW - Solubility

UR - https://www.scopus.com/pages/publications/47949125776

U2 - 10.1016/j.ejmech.2007.09.030

DO - 10.1016/j.ejmech.2007.09.030

M3 - 文章

C2 - 18215444

AN - SCOPUS:47949125776

SN - 0223-5234

VL - 43

SP - 1791

EP - 1795

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 8

ER -

Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies

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