TY - JOUR
T1 - Photoactivatable hydrogen sulfide donors for visualizing H2S controlled release in accelerated chronic wound healing
AU - Lin, Jia
AU - Ding, Le
AU - Wu, Yingting
AU - Li, Haoyang
AU - Wu, Yi
AU - Li, Chen
AU - Zhu, Quangang
AU - Chen, Zhongjian
AU - Cui, Xiaoyan
AU - Wang, Ting
N1 - Publisher Copyright:
© 2026
PY - 2026/10
Y1 - 2026/10
N2 - Hydrogen sulfide (H2S) is a pivotal endogenous gaseous signalling molecule involved in various physiological processes. Although H2S exhibits significant anti-inflammatory effects at physiological concentrations, its clinical utility is hindered by the challenges associated with its high activity and difficulties in controlled release. We designed three photoactivatable H2S donors, HSDs (HSD1, HSD2, and HSD3), by integrating an H2S-releasing 1,4,2-dioxazole-5-thione scaffold with three fluorophores spanning the ultraviolet to red spectral range. Upon photo-irradiation, each donor induces a pronounced turn-on fluorescence (>58-fold), accompanied by efficient H2S release (over 30 %) without the formation of electrophilic by-products. Moreover, HSDs enable real-time quantitatively photo-triggered H2S-release in both live cells and murine models, and present anti-inflammatory and antioxidant effects in vivo. In a full-thickness cutaneous wound model, HSDs markedly accelerated wound healing, highlighting their potential as precision therapeutic agents for wound management. Collectively, we provide a translatable strategy to overcome the limitations of conventional H2S delivery systems and highlight the therapeutic promise of controlled H2S release in clinical application.
AB - Hydrogen sulfide (H2S) is a pivotal endogenous gaseous signalling molecule involved in various physiological processes. Although H2S exhibits significant anti-inflammatory effects at physiological concentrations, its clinical utility is hindered by the challenges associated with its high activity and difficulties in controlled release. We designed three photoactivatable H2S donors, HSDs (HSD1, HSD2, and HSD3), by integrating an H2S-releasing 1,4,2-dioxazole-5-thione scaffold with three fluorophores spanning the ultraviolet to red spectral range. Upon photo-irradiation, each donor induces a pronounced turn-on fluorescence (>58-fold), accompanied by efficient H2S release (over 30 %) without the formation of electrophilic by-products. Moreover, HSDs enable real-time quantitatively photo-triggered H2S-release in both live cells and murine models, and present anti-inflammatory and antioxidant effects in vivo. In a full-thickness cutaneous wound model, HSDs markedly accelerated wound healing, highlighting their potential as precision therapeutic agents for wound management. Collectively, we provide a translatable strategy to overcome the limitations of conventional H2S delivery systems and highlight the therapeutic promise of controlled H2S release in clinical application.
KW - Controlled release
KW - HS donors
KW - No by-products
KW - Photo-activation
KW - Wound healing
UR - https://www.scopus.com/pages/publications/105043903403
U2 - 10.1016/j.cclet.2025.112100
DO - 10.1016/j.cclet.2025.112100
M3 - 文章
AN - SCOPUS:105043903403
SN - 1001-8417
VL - 37
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
IS - 10
M1 - 112100
ER -