Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones: Access to α-trifluoromethyl γ-carbonyl nitriles

Tao Zhou; Xin Ji; Junliang Zhang; Lu Liu

doi:10.1039/d0qo00582g

Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones: Access to α-trifluoromethyl γ-carbonyl nitriles

Tao Zhou
, Xin Ji
, Junliang Zhang^*
, Lu Liu^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Fudan University

科研成果: 期刊稿件 › 文章 › 同行评审

15 引用（Scopus）

摘要

Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.

源语言	英语
页（从-至）	2644-2648
页数	5
期刊	Organic Chemistry Frontiers
卷	7
期	18
DOI	https://doi.org/10.1039/d0qo00582g
出版状态	已出版 - 21 9月 2020

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10.1039/d0qo00582g

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abstract = "Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.",

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T2 - Access to α-trifluoromethyl γ-carbonyl nitriles

AU - Zhou, Tao

AU - Ji, Xin

AU - Zhang, Junliang

AU - Liu, Lu

PY - 2020/9/21

Y1 - 2020/9/21

N2 - Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.

AB - Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.

UR - https://www.scopus.com/pages/publications/85093512158

U2 - 10.1039/d0qo00582g

DO - 10.1039/d0qo00582g

M3 - 文章

AN - SCOPUS:85093512158

SN - 2052-4110

VL - 7

SP - 2644

EP - 2648

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 18

ER -

Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones: Access to α-trifluoromethyl γ-carbonyl nitriles

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