PH-Operated Triplex DNA Device on MoS                         2                          Nanosheets

Wei Ji; Dan Li; Wei Lai; Xiaowei Yao; Md Fazle Alam; Weijia Zhang; Hao Pei; Li Li; Arun Richard Chandrasekaran

doi:10.1021/acs.langmuir.8b04272

PH-Operated Triplex DNA Device on MoS ₂ Nanosheets

Wei Ji
, Dan Li
, Wei Lai
, Xiaowei Yao
, Md Fazle Alam
, Weijia Zhang
, Hao Pei
, Li Li^*
, Arun Richard Chandrasekaran

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Fudan University
SUNY Albany

科研成果: 期刊稿件 › 文章 › 同行评审

19 引用（Scopus）

摘要

We report a triplex-based DNA device coupled with molybdenum disulfide (MoS ₂ ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS ₂ nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS ₂ nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.

源语言	英语
页（从-至）	5050-5053
页数	4
期刊	Langmuir
卷	35
期	14
DOI	https://doi.org/10.1021/acs.langmuir.8b04272
出版状态	已出版 - 9 4月 2019

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10.1021/acs.langmuir.8b04272

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引用此

@article{fd4fa9e396874c09ac860f59c8563791,

title = " PH-Operated Triplex DNA Device on MoS 2 Nanosheets ",

abstract = " We report a triplex-based DNA device coupled with molybdenum disulfide (MoS 2 ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS 2 nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS 2 nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.",

author = "Wei Ji and Dan Li and Wei Lai and Xiaowei Yao and Alam, \{Md Fazle\} and Weijia Zhang and Hao Pei and Li Li and Chandrasekaran, \{Arun Richard\}",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = apr,

day = "9",

doi = "10.1021/acs.langmuir.8b04272",

language = "英语",

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T1 - PH-Operated Triplex DNA Device on MoS 2 Nanosheets

AU - Ji, Wei

AU - Li, Dan

AU - Lai, Wei

AU - Yao, Xiaowei

AU - Alam, Md Fazle

AU - Zhang, Weijia

AU - Pei, Hao

AU - Li, Li

AU - Chandrasekaran, Arun Richard

PY - 2019/4/9

Y1 - 2019/4/9

N2 - We report a triplex-based DNA device coupled with molybdenum disulfide (MoS 2 ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS 2 nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS 2 nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.

AB - We report a triplex-based DNA device coupled with molybdenum disulfide (MoS 2 ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS 2 nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS 2 nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.

UR - https://www.scopus.com/pages/publications/85064202726

U2 - 10.1021/acs.langmuir.8b04272

DO - 10.1021/acs.langmuir.8b04272

M3 - 文章

C2 - 30879305

AN - SCOPUS:85064202726

SN - 0743-7463

VL - 35

SP - 5050

EP - 5053

JO - Langmuir

JF - Langmuir

IS - 14

ER -

PH-Operated Triplex DNA Device on MoS 2 Nanosheets

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PH-Operated Triplex DNA Device on MoS ₂ Nanosheets