Peptide p3 may play a neuroprotective role in the brain

Wenfei Han; Tingting Ji; Bing Mei; Jiansheng Su

doi:10.1016/j.mehy.2010.12.013

Peptide p3 may play a neuroprotective role in the brain

Wenfei Han
, Tingting Ji
, Bing Mei^*
, Jiansheng Su

^*此作品的通讯作者

心理与认知科学学院

Tongji University
East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.

源语言	英语
页（从-至）	543-546
页数	4
期刊	Medical Hypotheses
卷	76
期	4
DOI	https://doi.org/10.1016/j.mehy.2010.12.013
出版状态	已出版 - 4月 2011

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title = "Peptide p3 may play a neuroprotective role in the brain",

abstract = "Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.",

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AB - Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.

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Peptide p3 may play a neuroprotective role in the brain

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