Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

Dong Xing; Dan Yang

doi:10.1021/ol401901h

Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

Dong Xing
, Dan Yang^*

^*此作品的通讯作者

化学与分子工程学院

The University of Hong Kong

科研成果: 期刊稿件 › 文章 › 同行评审

48 引用（Scopus）

摘要

A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.

源语言	英语
页（从-至）	4370-4373
页数	4
期刊	Organic Letters
卷	15
期	17
DOI	https://doi.org/10.1021/ol401901h
出版状态	已出版 - 6 9月 2013

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10.1021/ol401901h

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title = "Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines",

abstract = "A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.",

author = "Dong Xing and Dan Yang",

year = "2013",

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T1 - Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

AU - Xing, Dong

AU - Yang, Dan

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Y1 - 2013/9/6

N2 - A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.

AB - A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.

UR - https://www.scopus.com/pages/publications/84883799270

U2 - 10.1021/ol401901h

DO - 10.1021/ol401901h

M3 - 文章

C2 - 23980544

AN - SCOPUS:84883799270

SN - 1523-7060

VL - 15

SP - 4370

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JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

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