Palladium-Catalyzed Dual C(sp2)-H Functionalization of Indole-2-carboxamides Involving a 1,2-Acyl Migration: A Synthesis of Indolo[3,2- c]quinolinones

Lingkai Kong; Zhong Zheng; Rong Tang; Mengdan Wang; Yue Sun; Yanzhong Li

doi:10.1021/acs.orglett.8b02419

Palladium-Catalyzed Dual C(sp²)-H Functionalization of Indole-2-carboxamides Involving a 1,2-Acyl Migration: A Synthesis of Indolo[3,2- c]quinolinones

Lingkai Kong
, Zhong Zheng
, Rong Tang
, Mengdan Wang
, Yue Sun
, Yanzhong Li^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
Linyi University

科研成果: 期刊稿件 › 文章 › 同行评审

23 引用（Scopus）

摘要

A novel Pd/Cu catalytic system to construct indolo[3,2-c]quinolinones has been developed starting from indole-2-carboxamides. Substrates were transformed into indolo[3,2-c]quinolinones through dual C(sp²)-H functionalization of the indole moiety and arene, in which a carbonyl 1,2-migration was involved. The corresponding products were obtained in moderate to excellent yields with a wide substrate scope.

源语言	英语
页（从-至）	5696-5699
页数	4
期刊	Organic Letters
卷	20
期	18
DOI	https://doi.org/10.1021/acs.orglett.8b02419
出版状态	已出版 - 21 9月 2018

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10.1021/acs.orglett.8b02419

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abstract = "A novel Pd/Cu catalytic system to construct indolo[3,2-c]quinolinones has been developed starting from indole-2-carboxamides. Substrates were transformed into indolo[3,2-c]quinolinones through dual C(sp2)-H functionalization of the indole moiety and arene, in which a carbonyl 1,2-migration was involved. The corresponding products were obtained in moderate to excellent yields with a wide substrate scope.",

author = "Lingkai Kong and Zhong Zheng and Rong Tang and Mengdan Wang and Yue Sun and Yanzhong Li",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = sep,

day = "21",

doi = "10.1021/acs.orglett.8b02419",

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T1 - Palladium-Catalyzed Dual C(sp2)-H Functionalization of Indole-2-carboxamides Involving a 1,2-Acyl Migration

T2 - A Synthesis of Indolo[3,2- c]quinolinones

AU - Kong, Lingkai

AU - Zheng, Zhong

AU - Tang, Rong

AU - Wang, Mengdan

AU - Sun, Yue

AU - Li, Yanzhong

PY - 2018/9/21

Y1 - 2018/9/21

N2 - A novel Pd/Cu catalytic system to construct indolo[3,2-c]quinolinones has been developed starting from indole-2-carboxamides. Substrates were transformed into indolo[3,2-c]quinolinones through dual C(sp2)-H functionalization of the indole moiety and arene, in which a carbonyl 1,2-migration was involved. The corresponding products were obtained in moderate to excellent yields with a wide substrate scope.

AB - A novel Pd/Cu catalytic system to construct indolo[3,2-c]quinolinones has been developed starting from indole-2-carboxamides. Substrates were transformed into indolo[3,2-c]quinolinones through dual C(sp2)-H functionalization of the indole moiety and arene, in which a carbonyl 1,2-migration was involved. The corresponding products were obtained in moderate to excellent yields with a wide substrate scope.

UR - https://www.scopus.com/pages/publications/85053347554

U2 - 10.1021/acs.orglett.8b02419

DO - 10.1021/acs.orglett.8b02419

M3 - 文章

C2 - 30183319

AN - SCOPUS:85053347554

SN - 1523-7060

VL - 20

SP - 5696

EP - 5699

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Palladium-Catalyzed Dual C(sp2)-H Functionalization of Indole-2-carboxamides Involving a 1,2-Acyl Migration: A Synthesis of Indolo[3,2- c]quinolinones

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Palladium-Catalyzed Dual C(sp²)-H Functionalization of Indole-2-carboxamides Involving a 1,2-Acyl Migration: A Synthesis of Indolo[3,2- c]quinolinones