Palladium-Catalyzed Coupling of Aryl Iodides with Sulfinamide Reagents for the Construction of Sulfinamides

Rutian Sun; Daming Zeng; Ming Wang; Xuefeng Jiang

doi:10.1002/chem.202502496

Palladium-Catalyzed Coupling of Aryl Iodides with Sulfinamide Reagents for the Construction of Sulfinamides

Rutian Sun
, Daming Zeng
, Ming Wang^*
, Xuefeng Jiang^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University
CAS - Fujian Institute of Research on the Structure of Matter
Henan Normal University
CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

A novel sulfinamide reagent was developed that enables the one-step installation of sulfinamides through palladium-catalyzed coupling with aryl iodides. This method offers distinct advantages, including the use of readily available starting materials and broad substrate compatibility. Moreover, the strategy was successfully extended to the synthesis of complex functional molecules. Mechanistic investigations reveal that the key intermediate undergoes base-promoted retro-Michael addition to afford the target product.

源语言	英语
期刊论文编号	e02496
期刊	Chemistry - A European Journal
卷	32
期	28
DOI	https://doi.org/10.1002/chem.202502496
出版状态	已出版 - 25 7月 2026

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10.1002/chem.202502496

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title = "Palladium-Catalyzed Coupling of Aryl Iodides with Sulfinamide Reagents for the Construction of Sulfinamides",

abstract = "A novel sulfinamide reagent was developed that enables the one-step installation of sulfinamides through palladium-catalyzed coupling with aryl iodides. This method offers distinct advantages, including the use of readily available starting materials and broad substrate compatibility. Moreover, the strategy was successfully extended to the synthesis of complex functional molecules. Mechanistic investigations reveal that the key intermediate undergoes base-promoted retro-Michael addition to afford the target product.",

keywords = "retro-michael addition, sulfinamide, sulfonamides, sulfonimidoyl",

author = "Rutian Sun and Daming Zeng and Ming Wang and Xuefeng Jiang",

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AU - Wang, Ming

AU - Jiang, Xuefeng

PY - 2026/7/25

Y1 - 2026/7/25

N2 - A novel sulfinamide reagent was developed that enables the one-step installation of sulfinamides through palladium-catalyzed coupling with aryl iodides. This method offers distinct advantages, including the use of readily available starting materials and broad substrate compatibility. Moreover, the strategy was successfully extended to the synthesis of complex functional molecules. Mechanistic investigations reveal that the key intermediate undergoes base-promoted retro-Michael addition to afford the target product.

AB - A novel sulfinamide reagent was developed that enables the one-step installation of sulfinamides through palladium-catalyzed coupling with aryl iodides. This method offers distinct advantages, including the use of readily available starting materials and broad substrate compatibility. Moreover, the strategy was successfully extended to the synthesis of complex functional molecules. Mechanistic investigations reveal that the key intermediate undergoes base-promoted retro-Michael addition to afford the target product.

KW - retro-michael addition

KW - sulfinamide

KW - sulfonamides

KW - sulfonimidoyl

UR - https://www.scopus.com/pages/publications/105015437508

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DO - 10.1002/chem.202502496

M3 - 文章

AN - SCOPUS:105015437508

SN - 0947-6539

VL - 32

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 28

M1 - e02496

ER -

Palladium-Catalyzed Coupling of Aryl Iodides with Sulfinamide Reagents for the Construction of Sulfinamides

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