Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

Yun Lin Liu; Jian Zhou

doi:10.1039/c2cc36665g

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

Yun Lin Liu
, Jian Zhou^*

^*此作品的通讯作者

化学与分子工程学院

East China Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

150 引用（Scopus）

摘要

We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.

源语言	英语
页（从-至）	4421-4423
页数	3
期刊	Chemical Communications
卷	49
期	39
DOI	https://doi.org/10.1039/c2cc36665g
出版状态	已出版 - 18 4月 2013

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10.1039/c2cc36665g

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abstract = "We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.",

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AU - Zhou, Jian

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N2 - We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.

AB - We report the first catalytic asymmetric cyanation of N-Boc ketoimines, which enables highly enantioselective synthesis of oxindole based α-amino nitriles. An unprecedented tandem aza-Wittig/Strecker reaction is also developed, emerging as a promising strategy for the catalytic asymmetric cyanation of ketoimines formed in situ from achiral ketones.

UR - https://www.scopus.com/pages/publications/84876570001

U2 - 10.1039/c2cc36665g

DO - 10.1039/c2cc36665g

M3 - 文章

AN - SCOPUS:84876570001

SN - 1359-7345

VL - 49

SP - 4421

EP - 4423

JO - Chemical Communications

JF - Chemical Communications

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Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

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