Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups

Zhigang Li; Qing Yang; Xuhong Qian

doi:10.1016/j.bmc.2005.05.006

Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups

Zhigang Li
, Qing Yang
, Xuhong Qian^*

^*此作品的通讯作者

Dalian University of Technology
East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

70 引用（Scopus）

摘要

A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C₁, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A₁, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C₂, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.

源语言	英语
页（从-至）	4864-4870
页数	7
期刊	Bioorganic and Medicinal Chemistry
卷	13
期	16
DOI	https://doi.org/10.1016/j.bmc.2005.05.006
出版状态	已出版 - 15 8月 2005
已对外发布	是

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title = "Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups",

abstract = "A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C1, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A1, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C2, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.",

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author = "Zhigang Li and Qing Yang and Xuhong Qian",

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T1 - Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents

T2 - Effects of intercalation, side chains, and substituent groups

AU - Li, Zhigang

AU - Yang, Qing

AU - Qian, Xuhong

PY - 2005/8/15

Y1 - 2005/8/15

N2 - A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C1, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A1, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C2, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.

AB - A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C1, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A1, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C2, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.

KW - Antitumor

KW - Intercalation

KW - Photocleaver

KW - Thiazole

UR - https://www.scopus.com/pages/publications/21744451160

U2 - 10.1016/j.bmc.2005.05.006

DO - 10.1016/j.bmc.2005.05.006

M3 - 文章

C2 - 15925513

AN - SCOPUS:21744451160

SN - 0968-0896

VL - 13

SP - 4864

EP - 4870

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 16

ER -

Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups

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