Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities

Tao Qiu; Xiaoyong Xu; Jianwen Liu; Xuhong Qian

doi:10.1016/j.dyepig.2009.04.007

Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities

Tao Qiu
, Xiaoyong Xu
, Jianwen Liu
, Xuhong Qian^*

^*此作品的通讯作者

East China University of Science and Technology
Changzhou University

科研成果: 期刊稿件 › 文章 › 同行评审

41 引用（Scopus）

摘要

Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.

源语言	英语
页（从-至）	127-133
页数	7
期刊	Dyes and Pigments
卷	83
期	1
DOI	https://doi.org/10.1016/j.dyepig.2009.04.007
出版状态	已出版 - 10月 2009
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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title = "Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities",

abstract = "Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.",

keywords = "A375 melanotic cancer cell, HL-60 leukemic cell, Perfluoroalkyl phthalocyanines, Photodynamic therapy, Photosensitizer, Synthesis",

author = "Tao Qiu and Xiaoyong Xu and Jianwen Liu and Xuhong Qian",

year = "2009",

month = oct,

doi = "10.1016/j.dyepig.2009.04.007",

language = "英语",

volume = "83",

pages = "127--133",

journal = "Dyes and Pigments",

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TY - JOUR

T1 - Novel perfluoroalkyl phthalocyanine metal derivatives

T2 - Synthesis and photodynamic activities

AU - Qiu, Tao

AU - Xu, Xiaoyong

AU - Liu, Jianwen

AU - Qian, Xuhong

PY - 2009/10

Y1 - 2009/10

N2 - Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.

AB - Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.

KW - A375 melanotic cancer cell

KW - HL-60 leukemic cell

KW - Perfluoroalkyl phthalocyanines

KW - Photodynamic therapy

KW - Photosensitizer

KW - Synthesis

UR - https://www.scopus.com/pages/publications/66049120954

U2 - 10.1016/j.dyepig.2009.04.007

DO - 10.1016/j.dyepig.2009.04.007

M3 - 文章

AN - SCOPUS:66049120954

SN - 0143-7208

VL - 83

SP - 127

EP - 133

JO - Dyes and Pigments

JF - Dyes and Pigments

IS - 1

ER -

Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities

摘要

联合国可持续发展目标

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