Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: Synthesis and biological evaluation

Hong Yin; Yufang Xu; Xuhong Qian; Yuanli Li; Jianwen Liu

doi:10.1016/j.bmcl.2007.02.015

Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: Synthesis and biological evaluation

Hong Yin
, Yufang Xu^*
, Xuhong Qian
, Yuanli Li
, Jianwen Liu

^*此作品的通讯作者

East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

23 引用（Scopus）

摘要

Novel tertiary amine N-oxides of naphthalimides were designed and synthesized as potential anticancer agents against hypoxic solid tumors. Although their ctDNA-binding affinities and cytotoxic activities against usual tumor cell lines were lower than those of corresponding amines, the N-oxides A1 and A4 showed hypoxia preference activities against A375 cells in vitro and might be used as interesting candidates of prodrug leads in hypoxic tumor cells.

源语言	英语
页（从-至）	2166-2170
页数	5
期刊	Bioorganic and Medicinal Chemistry Letters
卷	17
期	8
DOI	https://doi.org/10.1016/j.bmcl.2007.02.015
出版状态	已出版 - 15 4月 2007
已对外发布	是

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abstract = "Novel tertiary amine N-oxides of naphthalimides were designed and synthesized as potential anticancer agents against hypoxic solid tumors. Although their ctDNA-binding affinities and cytotoxic activities against usual tumor cell lines were lower than those of corresponding amines, the N-oxides A1 and A4 showed hypoxia preference activities against A375 cells in vitro and might be used as interesting candidates of prodrug leads in hypoxic tumor cells.",

keywords = "Biological evaluation, Hypoxic solid tumor, N-Oxide of naphthalimides, Prodrug leads, Synthesis",

author = "Hong Yin and Yufang Xu and Xuhong Qian and Yuanli Li and Jianwen Liu",

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T2 - Synthesis and biological evaluation

AU - Yin, Hong

AU - Xu, Yufang

AU - Qian, Xuhong

AU - Li, Yuanli

AU - Liu, Jianwen

PY - 2007/4/15

Y1 - 2007/4/15

N2 - Novel tertiary amine N-oxides of naphthalimides were designed and synthesized as potential anticancer agents against hypoxic solid tumors. Although their ctDNA-binding affinities and cytotoxic activities against usual tumor cell lines were lower than those of corresponding amines, the N-oxides A1 and A4 showed hypoxia preference activities against A375 cells in vitro and might be used as interesting candidates of prodrug leads in hypoxic tumor cells.

AB - Novel tertiary amine N-oxides of naphthalimides were designed and synthesized as potential anticancer agents against hypoxic solid tumors. Although their ctDNA-binding affinities and cytotoxic activities against usual tumor cell lines were lower than those of corresponding amines, the N-oxides A1 and A4 showed hypoxia preference activities against A375 cells in vitro and might be used as interesting candidates of prodrug leads in hypoxic tumor cells.

KW - Biological evaluation

KW - Hypoxic solid tumor

KW - N-Oxide of naphthalimides

KW - Prodrug leads

KW - Synthesis

UR - https://www.scopus.com/pages/publications/33947595807

U2 - 10.1016/j.bmcl.2007.02.015

DO - 10.1016/j.bmcl.2007.02.015

M3 - 文章

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AN - SCOPUS:33947595807

SN - 0960-894X

VL - 17

SP - 2166

EP - 2170

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: Synthesis and biological evaluation

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