Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

Hong Yin; Weiping Zhu; Yufang Xu; Min Dai; Xuhong Qian; Yuanli Li; Jianwen Liu

doi:10.1016/j.ejmech.2011.04.040

Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

Hong Yin
, Weiping Zhu
, Yufang Xu^*
, Min Dai
, Xuhong Qian
, Yuanli Li
, Jianwen Liu

^*此作品的通讯作者

East China University of Science and Technology

科研成果: 期刊稿件 › 文章 › 同行评审

31 引用（Scopus）

摘要

A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.

源语言	英语
页（从-至）	3030-3037
页数	8
期刊	European Journal of Medicinal Chemistry
卷	46
期	7
DOI	https://doi.org/10.1016/j.ejmech.2011.04.040
出版状态	已出版 - 7月 2011
已对外发布	是

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title = "Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor",

abstract = "A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.",

keywords = "Bioreduction, Fluorescent marker, Hypoxic, N-Oxide, Naphthalimide",

author = "Hong Yin and Weiping Zhu and Yufang Xu and Min Dai and Xuhong Qian and Yuanli Li and Jianwen Liu",

year = "2011",

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T1 - Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

AU - Yin, Hong

AU - Zhu, Weiping

AU - Xu, Yufang

AU - Dai, Min

AU - Qian, Xuhong

AU - Li, Yuanli

AU - Liu, Jianwen

PY - 2011/7

Y1 - 2011/7

N2 - A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.

AB - A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.

KW - Bioreduction

KW - Fluorescent marker

KW - Hypoxic

KW - N-Oxide

KW - Naphthalimide

UR - https://www.scopus.com/pages/publications/79957454838

U2 - 10.1016/j.ejmech.2011.04.040

DO - 10.1016/j.ejmech.2011.04.040

M3 - 文章

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AN - SCOPUS:79957454838

SN - 0223-5234

VL - 46

SP - 3030

EP - 3037

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

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